What is the purpose of the dozens of p53 modificationsSoluti

What is the purpose of the dozens of p53 modifications?

Solution

p 53 under stress is enzymatically modified and it is done via phosphorylation at multiple residues. The mutation in p53 switches the cellular transcription program leading to deregulation of stress response which helps in maintaining cell and tissue integrity. p53 is a stress activated transcription factor which activates itself in case of stress which is sequence specific DNA binding protein. The purpose of p53 modification helps in promoting many repair processes including removal of damaged protein, generation of ATP through oxidative phosphorylation, DNA repair, mitochondrial function, programmed cell death, cell division cycle. The purpose of the dozens of p53 modifications helps in effortless regulation of body.