Select the most likely role of Notch1 a Helps to determine t

Select the most likely role of Notch-1

a. Helps to determine the fate of live cells

b. Helps to determine the fate of the thymus

c. Block the development of leukocytes

d. Helps determine the fate of lymphocytes

I thought the answer is D. because the notch-1 deals with live cells and their fate. my friend got a different answer so i am confused.

Solution

Notch 1 factors regulate the gene expression as transcription level and help regulate the choice between types of lymphocytes (i.e. T or B lymphocytes). The T lymphocyte progenitors express the Notch 1 receptors. The Notch ligands on these receptors are contacted upon by notch 1 to activate the differentiation of T cells. Correct answer is D.