Glucose has been found to react nonenzymatically with hemogl

Glucose has been found to react nonenzymatically with hemoglobin, through Schiff base formation between C?1 of glucose and the amino termini of the ? chains. How might this finding be applied in monitoring diabetic patients?

Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Reset Help adipocytes Glucosylated hemoglobin accumulates in the of diabetics and can easily be at the time of blood sampling measured. Because the glycosylation reaction is the level of glucosylated whereas a single determination of hemoglobin reflects the level of blood glucose noncovalent glucose reflects the value Thus, diabetes control can be monitored short-term with greater accuracy ifglucosylated hemoglobin is measured. Covalent brain over a period of about six months over a period of about four months blood longer-term

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Answer:

Glucosylated hemoglobin accumulates in the blood of diabetics and can easily be measured. Because the glycosylation reaction is covalent, the level of glucosylated haemoglobin reflects the level of blood glucose over a period of four months, whereas a single determination of glucose reflects the value at the time of blood sampling. Thus, longer term diabetes control can be monitored with greater accuracy if glucosylated hemoglobin is measured.