What is an imprinting control region ICR and how does it reg

What is an imprinting control region (ICR) and how does it regulate the expression of imprinted genes in an imprinted cluster?

Solution

imprinting control region (ICR) is a chromosomal region which acts, in a methylation-sensitive way, to determine whether the imprinted genes are expressed or not according to the parent from which the gene derived. Imprinted gene clusters are regulated by cis-acting sequences that function over a long-range depicted here as imprinting control regions which carry methylation imprints differentially acquired in the male and female germ-lines.