1 The acute toxicity of a compound after intraperitoneal inj

1. The acute toxicity of a compound after intra-peritoneal injection was assessed in various species and the major organs examined for evidence of necrosis(+) or absence of necrosis(-):

Species

LD 50

Mg.Kg^-1 body wt

Necrosis

Lung

Necrosis

Liver

Necrosis

Kidney

Rat (Sprague Dawley)

23

+

-

-

Mouse(C57BL/6J)

23

+

-

+

Bird(Japanese Quail)

75

-

+

-

Discuss these results and suggest possible explanations for the results obtained.

Describe briefly further experiments you would carry out to test your proposals.

Solution

The test for toxicity screening clearly suggests that the compound tested has high toxicity in rats tested, that is high mammalian toxicity.

Thus the compound or chemical tested is not preferred to expose human and other mammals.

If the compound is a drug then it should be used for treating humans.