please helpwith the right answerthis is a second post and th

please help...with the right answer-this is a second post and the answers were wrong

Practice Problem 122

Programmed cell death, also called apoptosis, is a genetically controlled event that helps shape organs and tissues during normal development. In the nematode C. elegans, normal development relies on three genes involved in programmed cell death, ced-3, ced-4, and ced-9.

Part A

In  C. elegans, ced-3 and ced-4 initiate the genetic events that lead to programmed cell death (apoptosis). The expression of ced-3 and ced-4 are controlled by ced-9.

The ced-9 gene acts as a \"binary switch\" in the genetic pathway controlling cell death, as shown in the diagram.

If ced-9 is active, ced-3 and ced-4 are repressed, allowing the cell to remain alive (and not undergo programmed cell death).

However, if ced-9 is inactive, ced-3 and ced-4 are expressed and initiate cell death.

For each mutation described below, determine whether it would result in cell survival or cell death.

Drag the terms to the appropriate blanks to complete the sentences. Terms can be used once, more than once, or not at all.

result in cell survival

result in cell death

have no effect on cell survival or cell death

1. A gain-of-function mutation in ced-9 would result in cell survival.

2. A loss-of-function mutation in ced-9 would result in cell death.

3. A gain-of-function mutation in ced-3 and a loss-of-function mutation in ced-9 would result in cell death.

4. A loss-of-function mutation in ced-4 and a gain-of-function mutation in ced-9 would result in cell survival.

5. A gain-of-function mutation in ced-3 and a gain-of-function mutation in ced-9 would have no effect on cell survival or cell death.

6. A loss-of-function mutation in ced-4 and a loss-of-function mutation in ced-9 would result in cell death.

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result in cell survival result in cell death have no effect on cell survival or cell death 1. A gain-of-function mutation in ced-9 would result in cell survival. 2. A loss-of-function mutation in ced-9 would result in cell death. 3. A gain-of-function mutation in ced-3 and a loss-of-function mutation in ced-9 would result in cell death. 4. A loss-of-function mutation in ced-4 and a gain-of-function mutation in ced-9 would result in cell survival. 5. A gain-of-function mutation in ced-3 and a gain-of-function mutation in ced-9 would have no effect on cell survival or cell death. 6. A loss-of-function mutation in ced-4 and a loss-of-function mutation in ced-9 would result in cell death.

ced-9 ced-3 On Ce Off Survival ced-4 ced-3 Cell On death ced-4 Off

Solution

1- A gain of fuction mutaion in ced 9 result cell survivival

2-loss of fcution mutation in ced 9result cell death.

3 A gain-of-function mutation in ced-3 and a loss-of-function mutation in ced-9 would result in cell death.

4. A loss-of-function mutation in ced-4 and a gain-of-function mutation in ced-9 would result in cell survival.

5. A gain-of-function mutation in ced-3 and a gain-of-function mutation in ced-9 would have no effect on cell survival or cell death.

6 A loss-of-function mutation in ced-4 and a loss-of-function mutation in ced-9 would result in cell survival.

you nicely answer all option but your last answer is inccorrect because loos of 4 means cell survive beacause ced 3 alone can not induce appoptosis. beacuse ced 4 induce ced 3 to perfomed apoptosis