Which DNA repair mechanism utilizes the Mut proteins BER NHE

Which DNA repair mechanism utilizes the Mut proteins? BER, NHEJ, Homologous Recombination, NER, Mismatch Repair

Solution

Answer:

Mismatch Repair

Explanation:

Mismatch repair is a highly conserved process from prokaryotes to eukaryotes. The first evidence for mismatch repair was obtained from S. pneumoniae (the hexA and hexB genes). Subsequent work on E. coli has identified a number of genes that, when mutationally inactivated, cause hypermutable strains. The gene products are, therefore, called the \"Mut\" proteins, and are the major active components of the mismatch repair system. Three of these proteins are essential in detecting the mismatch and directing repair machinery to it: MutS, MutH and MutL (MutS is a homologue of HexA and MutL of HexB).

MutS is a mismatch repair (MMR) protein that increases the fidelity of DNA replication 100-1,000 times. MutS, with the help of two other MMR proteins, MutH and MutL, recognizes and repairs numerous errors, including mismatches, unpaired bases, and small insertion or deletion loops.