Homework SourseA decrease have no effect on B decrease decrease C increase
A. decrease, have no effect on
B. decrease, decrease
C. increase, increase
D. increase, decrease
E. decrease, increase
| A mutation leads to a decrease in the concentration of MyoD. This would most likely lead to a(n) _______ of p21 expression, which would _______ the activity of cyclin-dependent kinases. |
Solution
E. decrease, increase.
One of the main actions of MyoD is to remove cells from the cell cycle by enhancing the transcription of p21 and myogenin. MyoD is inhibited by cyclin dependent kinases (CDKs). CDKs are in turn inhibited by p21. Thus MyoD enhances its own activity in the cell in a feedforward manner.
Mutation leading to decrease in concentration of MyoD will cause decrease in expression of p21 and will increase expression of CdK.
