04 Suggest why the constitutional isomer 6 is not produced t

#04. Suggest why the constitutional isomer 6 is not produced to any significant amounts in the Friedel- Crafts reaction you performed. CH OCH3 CH OCH3 CH +2 CH3 C-OH + 2 H2O H2SO4 CH3O CH CH3O 2 6

Solution

tertiary butyl group is too large and causes steric hindrance therefore it is highly unfavorable

friedel craft acylation of 1,4-dimethoxybenzene with tert-butyl alcohol  generates 1,4-di-tert-butyl-2,5-dimethoxybenzene .