Describe in a detailed explanation for the following a Estim

Describe in a detailed explanation for the following:

a. Estimate the maximal number of generations a somatic cell might be capable of before potential loss of gene functions, if the cell had telomeres ranging in size from 5000bp to 20,000bp. Assume loss of 200 bp from atelomere during each generations and no telomerase activity.

b. Explain the activity and functions of the chromatin remodling complex in detail.

Solution

A. Number of base pairs in telomeres is 5000-20,000.

At each cell cycle, 200 base pairs are lost from a telomere.

Therefore total number of generations a cell can undergo is

5000-2000÷ 200 = 25-1000.

Total number of cell generations is 25 to 100.