Explain triparental embryosSolutionInherited mitochondrial d

Explain triparental embryos

Solution

Inherited mitochondrial disorder affected between 1-5000 to 1-8000 people. There are a heterigeneous group of maternally inherited disorders, such as heart and liver failure,defect in energy metabolism, blindness, deafness, loss of motor skill and premature death.

To avoid this disease two technique have been proposed. The first involves the removal of the oocyte meiotic spindle (nuclear DNA) from the donor oocyte and replacing it with the meiotic spindle from the intending mother oocyte (the person at risk for transmitting mitochondrial disease , thereby providing healthy mitochondria. The reconstitute oocyte is then fertilized with sperm from the intending father or donor.

The alternative procedure involves pro nuclear transfer to donor oocyte whereby the intending mother oocyte is fertilized using IVF and two pro nuclei (one male and one female) are removed and transfer into the enucleated donor zygote at the same stage of development.

The proposed technique will give the resulting child from both intending parents plus DNA from the donor oocyte mitochondria. In essence creating three patent embryos.