Core oligosaccharide synthesis is initiated in the cytosol and completed in the rER lumen. How does this transfer occur?
| | 1) | Using cotranslational modifications. | |
| | 2) | All of the above aid in this transfer. | |
| | 3) | Flipase enzyme flips the growing oligosaccharide into the lumen. | |
| | 4) | When the pH of the rER lumen drops to 5. 0. | |
| | 5) | Transcription will trigger this change. | |
Option 3) Flipase enzyme flips the growing oligosaccharide into lumen.These are of three types basically which are given below:
These flippase are not directly involved in the movement of oligosaccharides across membrane. They utilize the polar lipid of the bilayer membrane. oligosaccharide binds with them and flippase flips the lipid molecule.
Low pH i.e 5 (Acidic) will hydrolyse the protein. Low pH helps the lysosomal activity.
Transcription will not trigger this change beacuse it happens before the translation. And the oligasccharide synthesis/modification/transfer are post translational steps.
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