Which of the following HAP ceramics do you believe would be

Which of the following HAP ceramics do you believe would be the most successful in repairing a bone defect made by the excision of a large tumor in a weight-bearing bone, and why? a. Nanocrystalline HAP on a porous collagen template. b. Sintered HAP containing silicon made at 1300 degree C c. Nanocrystalline HAP sintered at 1150 degree C d. Sintered HAP made from bovine bone at 700 degree C

Solution

The answer is (A) Nanocrystalline HAP on a porous collagen template because of the following reasons.

1) Nano materials have superior fracture toughness and strength when compared with the conventional materials. They also have excellent torsion modulus. Thus they last long than the conventional materials.

2) Porous structure of the ceramics is needed to create a microenvironment for attaining cell adhesion and proliferation

3) Natural biomaterials like collagen exhibit good biocompatibility and have cellular affinity. They can be easily absorbed by the body. Collagen scaffolds also promote formation of new blood vessels and bone regeneration.