1 How are various Reovirusstructural particles used for its

1. How are various Reovirus“structural particles” used for its mRNA transcription and dsRNAreplication?

2. Is Hepatitis delta virus (HDV) dependent on a host cell for its RNA transcription?

3. If Prionsare only protein with no nucleic acid how are they “self-replicating” entities?

please answer all three questions thuroughly and correctly. thank you!

Solution

1. Role of structural protein in replication

Role of structural protein in transcription

2. HDV is a small spherical virus whose nucleocapsid contains single stranded circular RNA but does not contain any RNA Polymerase to transcribe its RNA.Thats why HDV must have to depend on host cell for RNA polymerase II.

3. Prion an infectious agent without nucleic acid is composed of only one type of prion protein(PrP). PrP with an abnormal structure is actually encoded by host normal genes after the infection which is capable of self-replication.