8 how can a SNP in the 1390 region lead to persistent lactas

8. how can a SNP in the 1390 region lead to persistent lactase expression? Formulate a hypothesis?

Solution

persistence lactase expression is a congenital defect. SNP mutation in lactose gene leads to the persistent lactase expression. however, no involved mechanism is known. it is hypothesized that SNP mutation leads to the non-binding of repressor molecule to the promoter region leading to continuous expression of genes. while some hypothesized that this mutation involves in transcriptional activation of promoter region which leads to the continuous expression of the gene. either of the above stated mechanism can lead to lactase persistence.