What cell cycle function will be impaired if the Rb is mutan

What cell cycle function will be impaired if the Rb is mutant? Be specific please, thank you

Solution

Rb or retinoblastoma is the gene which encodes for retinoblastoma protein or pRb. This protein is highly active in nature and has direct regulatory effects on cell cycle. By modulation of cell cycle, this protein actively regulates the rate of cellular proliferation by differential regulation of various cell dependent kinases. Thus, it can be deciphered that functional impairments in this gene or function of this protein can be deletrious to the cell by faulty cell cycle regulation. Studies have shown that impaired Rb expression and hence impaired pRb function leads to direct modulation and defects in cell cycle. Excessive cellular proliferation due to uncontrolled cell division has been observed in cells with faulty Rb gene and pRb proteins. This is why this gene and protein remain important targets for cancer therapeutics.

Thus, it can be deciphered that impaired or mutant Rb is directly associated with defects in cell cycle control leading to excessive cellular proliferation and hence promote cancerous growth.