Thanks Cida deficiency drives peemanure aging Figure Mitocho

Cida deficiency drives peemanure aging Figure Mitochondrial degeneration and autophagy induction in the muscles and neurons of the Cisd2 mice. (Al Wild-type mitochondria in the brain (hippo- campus IB) A Cisd2 in the brain (hippocampus. Note that the outer mitochondrial mem brane has broken down larrowheadl, while the inner cristac appear to be intact. IC) Cisd2 mitochondria in sciatic nerve. One mitochondrion (arrowhead) has a destroyed OM, but with cristae still visible, the other mitochondrion (arrowl has destroyed OMs and LMs. (DI Wild-type mitochondria in cardiac muscle. El Cisd2 mitochondria in cardiac muscle. This micrograph shows one mitochondrion larrowheadl with a destroyed OM and two degenerated mitochondria consisting of debris arrowsl. IF A cluster of autophagic vacuoles and abnor mal mitochondria was observed between the myofibrils of Cisd2 1- skeletal muscle (white arrows]. (G) A wild type myelinated axon of the sciatic nerve. (NINucleus of Schwann cell, IMS) sheath. (H) A myelinated axon of sciatic nerve from a Cisd2 mouse. An ovoid with a ing myelin sheath and a degenerating axonal component are shown. In Debris from an axon U-LI Early or Avis enclosing mitochondria larrows] and Late or Avds were detected in the axonal component and cytoplasm of a Schwann cell from a 2-wk old Cisda sciatic nerve, lM,N Percentage of myelinated axons present in the sciatic nerves showing disintegration of their myelin sheaths and autophagic vacuoles, AVi and AVd, in their axonal component. There were three mice for cash group. lol Westen bTotting to detected the Pl Ratios of Cadac skeletal Cardar skeletal Cardac saeleul for each group P

Solution

1. Mitochondria, a cell organelle that is found in cell responsible for generation of ATP(Adenosine Tri Phosphate- a energy molecule) denegerates causing hinderence in its function of providing and formation of energy leading to non function of the cell or organs. This is due to the Cisd2 genes.

2. These Cisd2 genes may lead to autophagic cell death due to disintegrating myelin sheath of sciatic nerve.

3.There is breakdown of mitochondrial membrane of sciatic nerves and cardiac muscle leading to degeneration of both nerves and muscles in the said animal.

4. As mitochondria is important cell organelle for both nerves and muscles its degeneration will lead to appearance of old age and death.