The purpose of this question is to synthesize processes of B cell development, activation, and differentiation into an ordered series of events. First decide whether the events below occur during B cell Development or Activation and Differentiation. Then order the events within those two (2) categories. 1. Clonal selection. 2. Receptor Editing. 3. Clonal expansion. 4. Antigen binding to BCR. 5. Formation of a germinal center. 6. Developing B cells express PAX5. 7. Secretion of \"primary wave\" of IgM antibodies. 8. A complete mIgM is expressed at the B cell surface. 9. The first pairing between heavy chains and light chains. 10. Activation of apoptosis in antibody generating plasma cells. 11. A heavy chain pair is complexed with the surrogate light chains. 12. mRNA splicing of H chain constant region switches from mu to delta. 13. B cell expresses more BCR of the IgD isotype than of the IgM isotype. 14. The highest affinity B cells steal antigen from their lower affinity counterparts. 15. Internalization of antigen bound BCRs and presentation of MCHII-peptide complex to T cell. 16. Cutting and rejoining of the heavy-chain DNA that results in a gamma, elementof, or alpha constant region lies directly downstream of the VDJ region.
B cell development
6. Developing B cell express PAX5.
16. Cutting and rejoining of the heavy chain DNA that results in a , € or constant regions lies directly downstream of the VDJ region.
12. mRNA splicing of H chains constant region switches from to
9. The first paring between heavy chains and light chains
11. A heavy chain pair is complexed with the surrogate light chains.
8. A complete mIgM is expressed at the B cell surface
13. B cell expresses more BCR of the IgD isotype than of the IgM isotype
2. Receptor editing
B cell activation and differentiation
5. Formation of a germinal center
4. Antigen biding to BCR
14. The highest affinity B cells steal antigen from their lower affinity counterparts
15. Internalization of antigen bound BCRs and presentation of MHC II-peptide complex to T cell
1. Clonal selection
3. Clonal expansion
7. Secretion of primary wave of IgM antibodies
10. Activation of apoptosis in antibody generating plasma cells
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