Two actual reactions that follow this pattern in glycolysis

Two actual reactions that follow this pattern in glycolysis (the breakdown of glucose) and gluconeogenesis (the synthesis of glucose) are shown below.

A. How do these reactions look like the reverse of each other and how are they not the reverse?

B. Why are the above reactions metabolically irreversible? Would these far from equilibrum reactions be irreversible outside the context of a metabolic pathway? How could you test your assertion?

Solution

A)

in case of the energy of ATp is used and converted in glucose 6 phophate and covnerted in ADP by using diffferent catalyst and that can change teh products ..here same glucose is seen ..only side products are change remanining all are same

B)

G= -RT ln Kc

here Kc is positive and here delta is negative so Kc will be very high and more forward reaction favours than back ward reaction..

forward reaction has high rate of converting into products so the reactions are irreversible

we can test by using difference in the Delta G values