Select the true statements from the list below 1 Regulation

Select the true statement(s) from the list below

. 1 Regulation of a linear metabolic pathway is likely to occur at the first step in the pathway, to prevent wasting energy on enzymatic reactions of later steps if the final product of the last reaction is not needed.

2 Glucose catabolism results in the formation of glycogen

3 Decreasing the availability of the first substrate in a metabolic pathway will decrease the rest of the metabolites in the pathway.

4 Metabolic flux will increase only when enzyme activity is high.

5 Glucose is converted to pyruvate via the glycolysis pathway.

6 Glucose, glycogen and glucagon are all carbohydrates that are involved in energy storage and metabolism.

I have tried 1&4 and 4&5, both answers were wrong. There is only one attempt left.

Solution

True:

1. Regulation of a linear metabolic pathway is likely to occur at the first step in the pathway, to prevent wasting energy on enzymatic reactions of later steps if the final product of the last reaction is not needed.

3. Decreasing the availability of the first substrate in a metabolic pathway will decrease the rest of the metabolites in the pathway.

5. Glucose is converted to pyruvate via the glycolysis pathway.

Glucose + 2 NAD⁺ + 2 ADP + 2 P_i 2 Pyruvate + 2 NADH + 2 H⁺ + 2 ATP + 2 H₂O

Reason:

2. Glucose anabolism (Building up process) results in the formation of glycogen while glycogen catabolism (breaking down process) results in glucose.

4. Metabolic flux will increase even if there is small increase in enzyme activity.

6. Glucose and glycogen are carbohydrates that are involved in energy storage and metabolism while glucagon is a hormone which induce glycogen metabolism to result in glucose.