Glucose6Phosphate dehydrogenase can have a mutation of its 2

Glucose-6-Phosphate dehydrogenase can have a mutation of its 238th residue. The lysine that is normally in this spot is switched to an arginine. This residue is the terminal residue of a beta sheet. how does this mutation affect the structure and function of the protein

Solution

Answer: Mutation of lysine to arginine at 238th residue can cause several structural and functional changes.This terminal residue is found near NADP⁺ site of glucose-6-phosphate dehydrogenase.Following are the structural changes that can be observed after mutation at 238th residue: