Write the steps from ACh binding to the muscarinic AChR to t

Write the steps from ACh binding to the muscarinic AChR to the synthesis of cAMP.

Solution

Steps from binding of ACh(Acetylcholine ) to muscarinic AChR to the synthesis of cAMP are

1] muscarinic acetylcholine receptors (metabotrophic Receptor ) are transmembrane proteins that interact with G-proteins

2] it causes a conformational change in receptor that is responsible for its association with & activation of intracellular G proteins .& converts GTP to GDP

3] Activated G protein then acts as an enzyme to catalyze downstream intracellular events

4] It results in inhibition of adenylate cycylase

5] There is stimulation of phospholipase C

6] decrease in production of cAMP