If a patient is given a 250 mg drug dose via IV bolus and ob

If a patient is given a 250 mg drug dose via IV bolus and obtains a C_max of 18.4 µg/mL, what is the V_D of this drug? Given this value, what would you predict about the drug’s properties? Please show work or explain if you can! Thanks!

Solution

Amount of drug in the body = 250 mg = 25*10⁴ µg = A
C_max = 18.4 µg/mL
Vd = A / C_max = 25*10⁴ µg / (18.4 µg/mL) = 13586.9565 mL = 13.5869 L
The drug is distributed all over the body.