25 Describe how unesterified fatty acids unlinked to CoA are

25: Describe how unesterified fatty acids unlinked to CoA are able to move through the aqueous environment of the cytoplasm. Also, describe how are cholesterol and phospholipids transported between organelles.

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Solution

Unesterified fatty acids within cells are commonly bound by fatty
acid–binding proteins which belong to a group of small cytosolic proteins that facilitate the intracellular movement of many lipids. These proteins contain a hydrophobic pocket lined by sheet. The ability of unesterified fattyacids to fit inside this pocket and interact non-covalently with the surrounding protein facilitates their intracellular movement. The transport ofcholesterol and phospholipids transported between organelles is Golgi-independent. It is proposed to be either by membrane-limited vesicles or other protein-lipid complexes, direct contact between membranes, or by transfer by small, soluble lipid-transfer proteins.Some combination of these processes islikely important.