ln hamsters the autosomal locus coding for the Bglobin chain

ln hamsters, the autosomal locus coding for the B-globin chain of hemoglobin is 2MU for the albino locus. Assume for the moment that the same is true for humans. Sickle cell anemia results from homozygosity for a particular mutation in B-globin gene.

What kinds of gametes will a daughter born to a normal man and a woman who has both albinism and sickle cell anemia form and in what portions

Solution

Answer:

H = Normal hemoglobin, h = Sickle cell hemoglobin

Father (AH/AH) * Mother (ah/ah)

Given the genes are separated by 2 m.u., parental gametes = 98% and recombinant gametes = 2%

Therefore,

Parental gametes: AH: 49%

                           ah: 49%

Recombinant gametes: Ah: 1%

                                  aH: 1%