Which is true of tumor angiogenesis Noninvasive tumors that

Which is true of tumor angiogenesis? Non-invasive tumors that have not breached the basement membrane can induce angiogenesis beyond the basement membrane. Angiogenesis is more intense prior to acquisition of invasiveness. Capillary density is negatively correlated with degree of malignancy. Breast cancer patients that are both HFR2- and VECF- have the poorest prognosis. Which is true of negative regulation of angiogenesis? During wound healing, hypoxia results in shutdown of angiogenesis. The Fas death receptor is displayed on actively proliferating endothelial cells, but is suppressed in the quiescent cells of mature capillaries. Tsp (thrombospondin)-1 selectively causes mature capillaries to regress, but has no effect on growing neovasculature. MMPs have strong anti-angiogenic activity. What is a particular advantage of anti angiogenesis therapy? Angiogenesis is widespread throughout the body, so drug delivery is simplified. The therapy targets genetically normal endothelial cells, which are less likely to generate drug-resistant variants than tumor cells are Anti-angiogenesis drugs preferentially affect the mature, quiescent capillaries associated with tumors but not normal tissues. Single doses are typically sufficient to eliminate tumor vasculature.

Solution

Please find the answers below:

Answer 4: Choice 1 (Angiogenesis is the feature of cancerous growth but different physiological relavance and characteristics than normal process. Cancerous angiogenesis is superficial in nature and does not penetrate the basement membrane of the tissue normally. However, extensive superficial angiogenesis prevents the transport of oxygen and nutrients to the underlying tissues thus depriving them of nutrients and redundant growth)

Answer 5: Choice 2 (Differential regulation of cellular death receptors during quinscent and proliferative stages modulates the growth of cells during different phases of cell proliferation. Since Fas ligands and receptors are directly involved in extracellular signal mediated cell-death in the cells and thus mediate regulation of apoptosis and cell growth)

Answer 6: Choice 2 (Cancerous growth is associated with extensive proliferation of small capillaries which arises due to cancerous growth of the endothelial cells. Thus, targeting drug therapies which prevent angiogenesis by destruction of these cancerous endothelial cells can directly help in eradicating the cancerous growth in the tissue without affecting other normal cells.)