Which of the following is the most toxic based on these oral

Which of the following is the most toxic based on these oral rat LD₅₀ values?

Lead, 20 mg / kg body eight

Aspirin, 1750 mg / kg body weight

Ethanol, 1000 mg / kg body weight

Nicotine, 2 mg / kg body weight

Solution

LD50 for Lead is 450 mg/ Kg body weight. Lead is present in 20 mg/ kg body weight which is less than LD50

LD50 for Aspirin is 200 mg/ Kg Body. Aspirin is present in 1750 mg/ Kg body weight.

So, the excess amout of Aspirin is : (1750-200)*100/ 200 % = 775%

LD50 for Ethanol is 7060 mg/ Kg body weight. Ethanol is present in 1000 mg/ kg body weight which is less than that of LD50.

LD50 for Nicotineis 50 mg/ Kg body weight. Nicotinel is present in 2 mg/ kg body weight which is less than that of LD50.

Only Aspirin is present in huge excess compared to LD50. So, it is the most toxic.