Kg values have been determined from binding curves of ligand

Kg values have been determined from binding curves of ligands A and B to protein P. If Kg for A is 106 M, and Kg for B is 10-4 M, this means that B. the rate of dissociation of B from P is faster than that of A from P A. the binding affinity for A to P is less than that of B to P F. the concentration of A is lower than that of B. C. A has a lower molecular weight than B E. A interacts more tightly with P than does B D. half of the binding sites for B will be occupied when [B]- 10-4 M You may select zero, one, or many answers

Solution

Answer:

High value of KD means low affinity

B. This is true as high value of KD means that the affinity will be less so B having high value of KD will disassociate faster

A. This is not true as it is reverse of what we discussed in A

F.Lower KD value means lower concentrations they are directly related, so A is having a lower concentration.

D. it is also true as 0= [L]/[L]+Kd thus = Kd/Kd+Kd = 1/2

E. This is also true as discussed in B

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