To enable it to be transmitted intact from one cell generati

To enable it to be transmitted intact from one cell generation to the next, the linear DNA molecule of a eukaryotic chromosome must have appropriate nucleotide sequences making up three special regions: origins of replication, a centromere and two telomeres. What would happen if such a chromosomal DNA molecule somehow lost: a. all of its origins of replication b. all of the DNA constituting the centromere c. one of its telomeres

Solution

a. If origin of replication of DNA is lost, thenthe binding of proteins to the site of origin is not possible. Then replication cannot as such start, since there is no unwinding of DNA

b.If the DNA constituting the centromere is lost, the chromosomes seggregate randomly and are lost

c.Telomeres are the ends of linear chromosomes, which contain repititve sequences that donot code for any particular gene.However integrity of the chromosome may be lost even though replication is not affected, if one of the telomere is lost.Telomeres mainly protect natural chromosome ends , from being recognised as damaged DNA.