The GABAergic system later in development is inhibitory howe

The GABAergic system later in development is inhibitory; however, early in development, this system is excitatory. This shift of the GABAergic system from excitatory to inhibitory is as the \"GABA shift.\" Explain shift in detail ensuring to mention key proteins that are involved in making this shift possible

Solution

The GABA; excitatory/inhibitory shift is due to the fact that, in immature neurons there is, initially a higher intracellular chloride concentration, leading to depolarizing leading, to excitatory actions of GABA and not the hyperpolarizing and inhibitory actions that are seen in mature neurons due to changes in the chloride levels.