Citrate synthase catalyzes the reaction Oxaloacetate acetyl

Citrate synthase catalyzes the reaction

Oxaloacetate + acetyl-CoA -> citrate + HS-CoA

The standard free energy change for the reaction is -31.5 kJ*mol^-1

(a) Calculate the equilibrium constant for this reaction at 37 degrees C.

(b) Would you expect this reaction to serve as a control point for its pathway (the citric acid cycle)?

Solution

Delta G= -RT lnK implies ....lnk= -(delta G)/RT = 31500/8.314*310 = 12.22 ..implies K= 2.1*10^5.......... Yes