Which of the following drugs inhibits nucleic acid synthesis

Which of the following drugs inhibits nucleic acid synthesis by inhibiting DNA gyrase? 5-fluorocytosine ritampin tetracycline quinolones

Solution

Correct answer is quinolones

Explanation: The quinolones including nalidixic acid and ciprofloxacin inhibit nucleic acid synthesis by inhibiting gyrase. Quinolones bind to these enzyme gyrase and prevent them from decatenation replicating DNA. Thus the antibiotic actions.