The following reaction is part of glycogen degradation and o

The following reaction is part of glycogen degradation and occurs inside a cell.

glucose-1-phosphate ? glucose-6-phosphate

The phosphoryl group transfer potential for glucose-1-phosphate is -20.9 kJ/mol and for glucose-6-phosphate is -13.8 kJ/mol. What is the K_eq (K) at 298 K? Is the conversion of glucose-1-phosphate to glucose-6-phosphate favorable or unfavorable under standard conditions?

Solution

For the given biological transformation,

The value of equilibrium constant for the reaction would be,

- K = 17.5 and the reaction is favourable

The reaction has a value and thus the reaction is spontaneous or favourable as written.