Which vitamin helps to metabolize some amino acidsSolutionVi

Which vitamin helps to metabolize some amino acids?

Solution

Vitamins helps to metabolize some amino acids are :

B-COMPLEX VITAMINS

Thiamine physiological role:

Thiamine functions as the co-enzyme thiamine pyrophosphate (TPP) in the metabolism of branched-chain amino acids and carbohydrates.

Specifically the Mg²⁺-coordinated TPP participates in the formation of a-ketols (e.g., among hexose and pentose phosphates) as catalysed by transketolase and in the oxidation of a-keto acids (e.g., pyruvate, a-ketoglutarate, and branched-chain a-keto acids) by dehydrogenase complexes.

Hence, when there is insufficient thiamine, the overall decrease in carbohydrate metabolism and its inter-connection with amino acid metabolism (via a-keto acids) have severe consequences, such as a decrease in the formation of acetylcholine for neural function.

Vitamin B₆ physiological role:

Vitamin B₆ (pyridoxine, pyridoxamine, and pyridoxal) Co-enzyme functions in metabolism of amino acids, glycogen, and sphingoid bases

These must be phosphorylated and the 5\'-phosphates of the first two oxidized to the functional PLP, which serves as a carbonyl-reactive co-enzyme to diverse enzymes involved in the metabolism of amino acids.

Example: Aminotransferases, decarboxylases, and dehydratases, d-aminolevulinate synthase in heme biosynthesis etc...