3How does renal failure cause the development of metabolic a

3.How does renal failure cause the development of:

metabolic acidosis

a)discuss effects on tissues

b)explain how the respiratory system tries to compensate

c)explain how the kidneys try to compensate

Solution

Only first question answered:

Q: How does renal failure cause the development of metabolic acidosis?

The normal pH of arterial blood is 7.4, whereas the pH of venous blood and interstitial fluids is about 7.35. Because the normal pH of arterial blood is 7.4, a person is considered to have acidosis when the pH falls below this value. acidosis occurs when the ratio of HCO3– to CO2 in the extracellular fluid decreases, thereby decreasing pH. If this ratio decreases because of a fall in HCO^3–, the acidosis is referred to as metabolic acidosis. [ If the pH falls because of an increase in P_CO2 (Partial pressure of CO2), the acidosis is referred to as respiratory acidosis]. During renal failure i.e; when kidney function declines markedly, there is a increase of the anions of weak acids in the body fluids that are not being excreted by the kidneys. In addition, the decreased glomerular filtration rate reduces the excretion of phosphates and NH4+, which reduces the amount of bicarbonate added back to the body fluids. Thus, renal failure can be associated with severe metabolic acidosis.