a What name is given to a drug that is similar in structure

a. What name is given to a drug that is similar in structure to the endogenous ligand and binds with that messenger\'s receptor to stimulate a cellular response? b. What name is given to a drug that is similar in structure to the endogenous ligand and binds with that messenger\'s receptor and blocks a cellular response? a. Name two components that are termed 2^nd messengers b. What is the function of a second messenger system Tyrosine kinases are enzymes that add a phosphate group to tyrosine amino acids on other proteins, changing the conformation of those proteins. True or False?

Solution

Answer:

6. a) Drug that is similar in strugture as endogenous ligands and binds with messengers receptor to stimulate response is called an Agonist.

b) drug that is similar in strugture as endogenous ligand binds with messengers receptor and blocks a cellular response is called Antagonist

7. a) 2nd messenger- i)Cyclic AMP, ii) Diacylglycerol (DAG)

b) Second messengers are small intracellular molecules that are produced after the first messenger (hormone or neurotransmitter)-dependent receptor activation. The first messengers may not physically cross the phospholipid bilayer to initiate changes within the cell directly (unlike steroid hormones). Due to this functional limitations of first messenger, the cell devise signal transduction mechanisms to transduce first messenger into second messengers, so that the extracellular signal may be propagated intracellularly. Most important feature of the second messenger system is that second messengers may be coupled downstream to multi-cyclic kinase cascades to greatly amplify the strength of the original first messenger signal.

8.Tyrosine kinases are enzymes that add a phosphate group to tyrosine amino acids on other proteins, changing the conformation of those proteins. This statement is -TRUE