You are studying the process of glycogen degradation in hepa

You are studying the process of glycogen degradation in hepatocytes (liver cells). To understand the role of this process in cell metabolism you add an inhibitor of glycogen degradation to a culture of liver cells. Under which of the following conditions do you predict this inhibitor would have an effect on liver cell function? SELECT ALL answers that are correct. 1. when the liver cell needs to store glycogen 2. when the liver cell uses stored glucose for fuel 3. when the liver cell needs to add glucose to the blood 4. when the liver cell uses blood glucose for fuel

Solution

glucose is stored in the liver cell in the form of glycogen. when blood glucose level lowers in liver hepatocyte cells glycogen are degraded to glucose. glucose residues in glycogen are linked to alpha 1,4 glycosidic bond. this pathway is controlled by allosteric enzymes.

when inhibitors of glycogen degradation added to liver hepatocyte cell the inhibitor show its effect - A. when the liver cell uses stored glucose for fuel, B. WHEN THE LIVER CELL NEEDS TO ADD GLUCOSE TO THE BLOOD.