Question Aspartate can be degraded to NH4 co2 and h20 to Bo

Question: Aspartate can be degraded to NH4, co2, and h20 to ... Bookmark Aspartate can be degraded to NH4, co2, and h20 to produce ATP energy by its carbons entering in the TCA cycle. How many ATP molecules can be generated from each molecule of this amino acid? (show Calculations using NADH=2.5 ATPS and FADH2=1.5 ATPS

Solution

Aspartate with the help of aspartate transaminase converted into 4 carbon compound Oxaloacetate and thus enter into Krebs cycle.

Oxaloacetate combines with Acetyl Co-A and converted into citric acid.

One complete Krebs cycle oxidizes Acetyl Co-A into two molecules of CO2 and produces 3 NADH. 1GTP and one FADH which overall give 10 ATP.

Aspartate is converted into four carbon Oxaloacetate. To oxidize it complete it has to go two complete Krebs cycle. So overall we will get 20 ATP from complete oxidation of Aspartate

In one Krebs cycle 3 NADH is produced which will give 3*2.5 ATP = 7.5 ATP

1 FADH which will give 1.5 ATP

1 GTP is produced which will get converted into 1 ATP

So upon adding we will get 7.5 + 1.5 + 1 = 10 ATP

In one cycle we will get 10 ATP

for complete oxidation of Oxaloacetate two cycle will be needed which will give 20 ATP