Importance of the RNA Polymerase lI CTDSolutionCTD of RNA po

Importance of the RNA Polymerase lI CTD.

Solution

CTD of RNA polymerase: The C-terminus of RPB1 is appended to form the C-terminal domain (CTD). The carboxy-terminal domain of RNA polymerase II typically consists of up to 52 repeats of the sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser. The domain stretches from the core of the RNAPII enzyme to the exit channel, this placement is effective due to its inductions of RNA processing reactions, through direct or indirect interactions with components of the RNA processing machinery. The CTD domain does not exist in RNA Polymerase I or RNA Polymerase III. Other proteins often bind the C-terminal domain of RNA polymerase in order to activate polymerase activity. It is the protein domain that is involved in the initiation of transcription, the capping of the RNA transcript, and attachment to the spliceosome for RNA splicing.