And 3rd neurological disease AIRE mice suffer from a severe

AIRE (-/-) mice suffer from a severe autoimmune syndrome leading to inflammation in peripheral tissues, anti-self-antibodies, and neurological disease. What is the function of AIRE in central tolerance? Why might knock it out lead to the autoimmune responses Inflammation (immune cell infiltration) in peripheral tissues\' Anti-self-antibodies?

Solution

8A)AIRE IN CENTRAL TOLERANCE:

In mammals ,central tolerance is established in the thymus (t cells ) and bone marrow (b cells).the thymus has an additional source of antigen through thE action of the transcription factors.AIRE AND FEZF2 which allows the Expression of organ specific antigens such as insulin in the thymus.

B) INFLAMMATION IN PERIPHERAL TISSUE:

In case such PERIPHERAL TISSUE tolerance were not induced the 2 reactions to self tissues Would be similar to those ..here this type INFLAMMATION occurs is originally induced in thymus and bone MARROW I.eCentral or into the other tissues and lymph nodes( PERIPHERAL) This also cause of auto immune disease , resulting in syndromes such as systemic lupus erythematous,Rheumatoid Arthritis,type 1 diabetes ,and auto immune polendocrine syndrome type 1.

ANTI SELF ANTIBODIES:

IT is a antibody produced by the immune system that is directed against onE or more of The individuals own proteins and many auto immune diseases (lupus erythematous are caused by such auto self ANTIBODIES .