Which of the following processes is an element of the dissol

Which of the following processes is an element of the dissolution and disassembly of the nuclear envelope at the end of prophase? Nuclear pore complexes are disassembled as interactions between the nucleoporin complexes are disrupted and the proteins dissociate into the surrounding medium. The nuclear lamina is disassembled by depolymerization of the lamin filaments. Nuclear membrane integrity is disrupted mechanically as holes are torn into the nuclear envelope by cytoplasmic dynein molecules associated with the outer nuclear membrane. All of these are correct answers.

Solution

Correct Answer is D = All of these are correct asnwer.

Dissoultion and disaasembly of the nuclear envelope takes place in three of its components:

An ideal way to understand these events is depolymerization of the nuclear lamina—the meshwork of filaments underlying the nuclear membrane. And the components of nuclear lamina are fibrous proteins, lamins, which associate with each other to form filaments. Due to the phosphorylation of the lamins, disassembly of the nuclear lamina occured, which leads to the filaments to break down into individual lamin dimers. Cdc2 protein kinase is responsible for the catalization of phosphorylation of the lamins.The different types of lamins are phosphorylates by the Cdc2 and treatment of isolated nuclei with Cdc2 has been shown to be sufficient to induce depolymerization of the nuclear lamina. Beside that the breakdown of the nuclear lamina which is the necessity of lamin phosphorylation shown directly by the construction of mutant lamins which can\'t be further phosphorylated. Gene expression was found to block normal breakdown of the nuclear lamina as the cells entered mitosis when genes encoding done into the mutant lamins were introduced into cells.