Rank the following carbonylcontaining compounds in order of

Rank the following carbonyl-containing compounds in order of reactivity towards nucleophilic acyl substitution.

Solution

butanoyl chloride > acetic propionic anhydride > isopropyl benzoate > benzamide

Among the carboxylic acid derivatives given, benzamide is the least reactive towards nucleophilic acyl substitution, followed by ester, then anhydrides and acid chlorides which are the most reactive.