Can someone tell me if this is a reasonable simplified expla

Can someone tell me if this is a reasonable simplified explanation of the role of MHC\'s and complement proteins in Lupus?

Defects in some major histocompatibility complex (MHC) genes are correlated with a higher incidence of SLE. MHC gene defects affect immunity because they code for certain proteins that recognize antigens as foreign. Defects in these genes can cause the immune system to lose that specificity and attack the body\'s own tissues. Other genes in MHCs code for complement proteins and a defect can dysregulate the immune system\'s inflammatory response (11).

Solution

Yes, as said above defects in MHC genes are correlated to lupus erythmatous cause these genes encode for the proteins that cause inflammatory responses against foreign antigens. Besides the MHC genes, defects in other genes can also be correlated as shown below Genes coding for proteins of opsonisation to elicit phag cytosis. Genes coding for cytokines like TN-alfa and IN-10.