I am taking the course for informatics in application to bio

I am taking the course for informatics in application to biological systems. And, my textbook is Mathematical Physiology, J. Keener, J. Sneid, Springer, 2009. And my background is mathematics so, I don\'t know about biology. My question is that,

\"Enzyme inhibition. Competitive and allosteric inhibitors. Describe the mechanisms.\"

Please tell me what the answer is. Thank you in advance.

Solution

Enzyme inhibition

A number of substances may cause a reduction in the rate of an enzyme catalysed reaction.it can be reversible or irreversible. irreversible inhibitor bound covalently to the enzyme and destroy the functional group in the active site. and reversible nhibitor involves non covalent binding

Competitive

a molecule similar to the substrate but unable to be acted on by the enzyme competes with the substrate for the active site. Because of the presence of the inhibitor, fewer active sites are available to act on the substrate. But since the enzyme\'s overall structure is unaffected by the inhibitor, it is still able to catalyze the reaction on substrate molecules that do bind to an active site. Note that since the inhibitor and substrate bind at the same site, competitive inhibition can be overcome simply by raising the substrate concentration.

allosteric inhibitors

Allosteric inhibition is the process by which a regulatory molecule binds to an enzyme in a spot different from the active site for another molecule. This causes a conformational change in the active site for the second molecule, preventing binding.