Humans with mutations in the AQP1 aquaporin1 gene do not pro

Humans with mutations in the AQP1 (aquaporin-1) gene do not produce the AQP1 protein. The absence of AQP1 causes an inability to ____ in these individuals. salivate make large volumes of dilute urine control sweating recognize thirst produce concentrated urine

Solution

In humans aquaporin 1 is a protein which is encoded by the AQP1 gene.

AQP1 is a widely expressed water channel, that is generally found in the kidney. It is present in the apical and basolateral surfaces of the proximal convoluted tubules, the descending thin limbs of the loop of Henle, and in the nonfenestrated endothelium of the descending vasa recta.

This integral protein increases the rate of water movement across the apical and basolateral membrane from tubular fluid, so that excess water does not discharge with urine.

But if AQP1 gene is mutated then aquaporin 1 does not work properly that means it does not absorbed water from tubular fluid and produces large volume of dilute urine.

So, the ans is option (ii) – makes large volumes of dilute urine.