You want to find all the genes that show increased expressio

You want to find all the genes that show increased expression in a pancreatic cell during diabetes. Design an experiment to do this.

Solution

The Experiment is trying to identiy the effect of STZ induced diabetes and GlP 1 mediated beta cell protection in STZ treated mice on genome wide expression pattern in pancreatic islets, when STZ is induced it led to activation of p53 responsive gene in affected islets ,

this experiment will help you to identify the potential diabetes associated genes, the fundamental cause of doing this experiment was to identiy why beta cells loose their functionality in individual with diabetes