Complete the table for each of these major NTs SolutionNeuro

Neurotransmitter

Receptor (remember to separate subtypes)

Chief Actions when stimulated

Acetylcholine

Muscarinic and Nicotinic acetyl choline receptors

Muscarinic receptor subtypes

muscarinic acetyl choline receptor M1

muscarinic acetyl choline receptor M2

muscarinic acetyl choline receptor M3

muscarinic acetyl choline receptor M4

muscarinic acetyl choline receptor M5

Nicotinic receptors

muscle type nicotinic receptors

neuronal-type nicotinic receptors (tweleve different subtypes include 210 and 24)

Muscarinic acetyl choline receptors (M1-M5) are involved in the large number of physiological functions including heart rate and force, contraction of smooth muscles, sensory control as well as more sensory control including arousal, memory and learning and release of neurotransmitters. All five are found in CNS, while M1-M4 are found in various tissues.

Nicotinic aceyl choline receptors plays very important role in neurotransmissions like synaptic transmission and paracrine transmission.nACHR mediates excitatory neurotransmission at neuronal junction in the brain and spinal cord. They also commonly involved in the modulation of neurotransmitter release or second messenger systems and calcium signaling.

Catecholamine

1A-adrenoceptor

1B-adrenoceptor

1D-adrenoceptor

2A-adrenoceptor

2B-adrenoceptor

2C-adrenoceptor

1-adrenoceptor

2-adrenoceptor

3-adrenoceptor

Adrenergic receptors have several functions in common when they stimulated. It causes the vasoconstriction in many blood vessels including skin, GI tract, kidney and brain.

The alpha2A receptor stimulates the release of glucagon and inhibits the insulin from pancreas

The alpha B1 receptor increases the cardiac output by increasing heart rate; renin secretion in kidney and ghrelin secretion in stomach

The alpha B2 receptor participates in smooth muscle relaxation, lipolysis in adiposse tissue and anabolism in skeletal muscle etc.,

Glutamate

Two types Metabotropic and Ionotropic receptors

Metabotropic receptors

mGlu1 receptor

mGlu2 receptor

mGlu3 receptor

mGlu4 receptor

mGlu5 receptor

mGlu6 receptor

mGlu7 receptor

mGlu8 receptor

Ionotropic receptors

AMPA receptors (subtypes: GluA1, GluA2, GluA3 and GluA4)

Kainate receptors (subtypes: GluK1, GluK2, GluK3, GluK4 and Gluk5)

NMDA receptors (subtypes: GluN1, GluN2A, GluN2B, GluN2C, GluN2D, GluN3A, GluN3B)

Delta receptors (subtypes: GluD1 and GluD2)

mGluRs have a variety of functions in the central and peripheral nervous system. They are involved in learning, memory, anxiety and perception of pain.

mGluRs also involved in neurotransmission, modulatin of post-synaptic signals and regulates the NMDA receptor activity

Ionotropic glutamate receptors are ligand-gated ion channels that are activated by the neurotransmitter glutamate. They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory

Aspartate

NMDA receptors (subtypes: GluN1, GluN2A, GluN2B, GluN2C, GluN2D, GluN3A, GluN3B)

NMDA receptor stimulates the synaptic transmission in the CNS which is important for behaviarol responses

GABA

GABA_A receptor

GABA_C receptor

GABA_B receptor (Subtypes: GABA_B1 and GABA_B2)

GABA recetors contributes to motor control, cognitive function, vision and many other cortical functions. They also regulates anxiety

Serotonin

5-HT1A receptor

5-HT1B receptor

5-HT1D receptor

5-ht1e receptor

5-HT1F receptor

5-HT2A receptor

5-HT2B receptor

5-HT2C receptor

5-HT4 receptor

5-ht5a receptor

5-ht5b receptor

5-HT6 receptor

5-HT7 receptor

Serotonin activates the cAMP to produce an excitatory and inhibitory resonse.

Serotonin receptors also regulates the cognitive functions such as addiction, aggression, mood, memory , impulsivity, respiration, sexual behavior, apetite, blood pressure, heart rate, cardiovascular activity, thermoreuglation, vasoconstriction and many other functions

Neuropeptides

NPFF1 receptor

NPFF2 receptor

NPS receptor

NPBW1 receptor

NPBW2 receptor

NPY1 receptor

NPY2 receptor

NPY4 receptor

NPY5 receptor

NPY6 receptor

Neuropeptides are short-chain polypeptides acts as neurotransmitters and gasotransmitters. They influence the activity of brain and body through neuronal signaling.

They involved in the wide range of functions that include learning and memory, analgesia, reproduction, metabolism and social behavior.