1 Two persons with the sickle cell trait marry and want to h

1. Two persons with the sickle cell trait marry and want to have children, but concerned about them having sickle cell anemia. What is the probability of sickle cell anemia in their children? What proportion of their children would you expect to be carriers?

2. If a person with the sickle cell trait marries a person with a normal hemoglobin, what is the probability they will have a child with sickle cell anemia? What proportion of their children would you expect to be carriers?

Solution

Answer:

1)

If both parents are having sickle cell anemia,then the out come is

I = Normal gene,   T: sickle cell trait

TI (One parent ) x TI (Another parent)

Possible genotypes:    TT, TI, TI, II

(TT)25% : not affected by sickle cell,

(TI)50%: carriers

(II)25%: affected by sickle cell

2)

Person with the sickle cell trait marries a person with a normal hemoglobin

TI (sickle cell trait person) x   II (Normal )

Possible genotypes: TI, TI, II,II

TI (50%) = carrier

II (50%)=   Unaffected by sickle cell.