explain the process by which growth factors promote angiogen

explain the process by which growth factors promote angiogenesis. (if you use any source please state the source, 8 sentences minimum)

Solution

Angigenesis is the process of development of new blood vessels that occurs during the normal development.Pathological angiogenesiis is also seen during some diseased conditions.

The regulation of angiogenesis is brought about due to a balance between the factors that promote the formation of the blood vessels and those that inhibit their formation.

As many as 20 endogenic positive regulators of angiogenesis have been recognised which include cytokines , growthfactors, interleukinsand matrixmetalloproteins.

The process of angigenesis is a multistep processand is controlled by a number of growth factors like vascular endothelial growth factor or the VEGF, basic fibroblas growth factorbFGF,granulocytic colony stimulating factos etc.

angiogenesis is inhibited by angistatins and the interferons.

The process of angiogenesis is a multi step process and can be described in the following steps:

Step 1:An endothelial cell gets activated by the growth factors VEGF<BFGF

Step 2: The capillary wall is degraded by theextracellular metallo proteinases.

Step 3 :Branch points are formed in the vessel wall.

Step 4 : the endothelial cells migrate into the extracellular matrix towards angiogenic stimulus.

Step 5 :The endothelial cells now get reorganized to form tubules with a central lumen.

Step 6:The new tubule so formed anastomose by establishing interconnections