What is the significance of doing wet lab studies versus in

What is the significance of doing wet lab studies versus in silica studies?

Solution

In silico studies are those studies which are directed to identify or generate a new molecule or study the interaction between target molecules using high-throughput computer simulated programmes. These programmes can simulate millions of tasks together and screen some most appropriate target sequences/interactions as an outcome. Such types of studies are routinely performed to analyse receptor-target based simulations, identification of receptor binding sites, identification and sequencing of host-pathogen interaction sites etc.

These in silico studies are highly significant because it is not possible practically to perform a wet-lab experiment every time to investigate a biological mechanism. However, after some potential results have been obtained by in silico simulations, a wet lab experimentation is important to be performed. This is because the target simulation products given by in silico experiments can be realised biologically only when they are actually tested in vitro or in vivo. This approach is highly significant because many in silico products which are generated by artificial simulation procedures might fail to produce a desired biological effect. Thus, in order to peform a biologically relevant and translational research, performing wet lab studies remains highly significant.